What characterizes an 'n-of-1' trial?

An 'n-of-1' trial is characterized as a highly individualized trial that assesses treatments for one patient over time. This approach allows for an in-depth evaluation of how a specific treatment affects an individual, tailoring the intervention to the unique responses and needs of that patient. It provides a way to determine the effectiveness of therapies for people whose conditions may not respond well to standard treatments that are derived from larger population studies.

In the context of medical research, 'n-of-1' trials stand out because they focus on the variability of response among individuals, recognizing that what works for one person may not work for another. This methodology is particularly useful in managing chronic conditions where treatment responses can differ widely, thus enabling healthcare practitioners and patients to make more informed decisions about personalized treatment options.